![]() Recent studies have additionally placed collective cell migration at the heart of metastasis of certain types of cancer ( Clark and Vignjevic, 2015 Wang et al., 2016). IntroductionĬollective cell migration is a fundamental process for embryonic development ( Szabó and Mayor, 2018) and its dysregulation during morphogenesis is a key contributor to many developmental disorders ( Friedl and Gilmour, 2009). These observations support a key role played by superficial primordium cells and the skin in directed migration of the Posterior Lateral Line primordium. When skinned embryos are embedded in Matrigel, basal and superficial lamellipodia are recovered however, only the directionality of basal protrusions is recovered, and migration is not rescued. Removal of the overlying skin has similar effects on superficial and deep cells: lamellipodia are lost, blebs appear instead, and collective migration fails. Polarization of lamellipodia extended by both superficial and deeper protoneuromast-forming cells depends on Fgf signaling. We describe a superficial population of flat primordium cells that wrap around deeper epithelialized cells and extend polarized lamellipodia to migrate apposed to the overlying skin. ![]() Its migration depends on the coordinated movement of its mesenchymal-like leading cells and trailing cells, which form epithelial rosettes, or protoneuromasts. The Zebrafish Posterior Lateral Line primordium migrates in a channel between the skin and somites. ![]()
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